Senior Scientist II, LC-MS/MS Small Molecule and Peptide In Vitro/In Vivo Bioanalysis

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

The Quantitative, Translational, and ADME Sciences (QTAS) Department at AbbVie is seeking a highly motivated and energetic bioanalytical Senior Scientist II to join the High-Throughput Automation Bioassay and Bioanalysis (HT-ABBA) group in North Chicago, IL. The main function of this position will be supporting LC-MS (Liquid Chromatography-Mass Spectrometry)-based bioanalysis, developing methods for Small Molecules and Peptides, and leading junior scientists. The ideal candidate will be experienced in development, optimization and implementation of LC-MS/MS bioanalytical methods to support In Vitro and pre-clinical In Vivo studies, as well as in managing junior scientists.

Responsibilities  

• Research and develop bioanalytical LC-MS/MS based methods for quantifying small molecules and peptides in biofluids and tissues.
• Perform high-throughput quantitative bioanalysis for In Vitro assays, PK/PD and TK studies of small molecules and peptides in biological matrices.
• Operate and maintain LC-MS/MS and automated instruments. Identify and troubleshoot instruments as needed.
• Investigate, evaluate, and implement new methodologies, platforms, and technologies to meet challenging assay requirements and throughput while maintaining effective resource utilization.
• Act as the bio-analyst leader on multiple projects, interacting with collaborators and project team representatives to understand study impact, define project needs and priorities, and present work internally and externally.
• Manage and mentor junior scientists.
• Maintain electronic laboratory notebooks (ELN) and manage study documentation in the Laboratory Information Management System (LIMS).

• PhD (4+ years), M.S. (10+ years), or B.S. (12+ years) in analytical chemistry or related field with relevant pharmaceutical industry experience with a focus on bioanalysis and mass spectrometry.
• Strong LC-MS/MS method development background with direct experience in bioanalysis/assays and understanding of both experimental design and analytical practices required.
• Expertise with current high-throughput LC-MS/MS platforms (e.g., Leap autosamplers, Sciex API-6500/7500 triple quadrupoles), software (e.g., Sciex Analyst and/or OS, Electronic notebooks, LIMS, Discovery Quant) and automated sample preparation (e.g., Hamilton, Tecan Dispenser) platforms.
• Working experience with high resolution MS (TOF or orbitrap) and/or EchoMS for the bioanalysis of small molecules and peptides will be a plus.
• Working experience of regulated bioanalysis and/or CRO settings will be a plus.
• Excellent personal, verbal, and written communication skills.
• Highly organized with keen attention to detail, enabling effective independent work and success within a matrix team environment.
• Desire to excel in a fast-paced environment, with strong problem-solving skills, and the ability to prioritize tasks and meet deadlines effectively.

Key Leadership Competencies

• Builds strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance, proven ability to collaborate successfully across other groups within R&D.
• Creates a learning environment, open to suggestions and experiments to drive the science in the field of interest.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality, learns fast, grasps the “essence” and can change course quickly when needed.
• Raises the bar and is never satisfied with the status quo.
• Highly motivated and self-driven with the flexibility to quickly adapt to different projects.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​.

​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html