Senior Scientist I - Purification Process Development


Worcester, MA

  1. Operations
  2. Biotechnology
  1. Full-time

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on TwitterFacebookInstagramYouTube and LinkedIn

Job Description

The Senior Scientist I will play a key role in the developing downstream purification process development for various modalities such as mAbs, ADCs, bio-specifics, gene therapy, etc. Ideal candidate will conceive and implement novel experimental and/or modeling approaches to answer scientific questions. The mission of this team is to address challenging problems in biologics development areas by working collaboratively and cross-functionally by developing appropriate tools and technologies to enable right at first pass scale-up and technology transfer of various biologics modalities drug substance processes.


  • Develop recovery and purification process that utilizes clarification, chromatography, and membrane filtration technologies for monoclonal antibodies, bio-specifics and antibody drug conjugates (ADC).
  • Proactively seek opportunities to come up with innovative solutions to cater challenging business problems through creative solutions.
  • Design and execute process development and characterization activities, impurity and viral clearance studies.
  • Provide deeper understanding of process performance using appropriate experimental and modeling tools.
  • Responsible for technology transfer to pilot lab and cGMP manufacturing facilities, troubleshooting and investigation activities.
  • Harness power of strong fundamentals to come up with innovative process and/or equipment designs in a strongly collaborative environment.
  • Build experimentally verified fit for purpose mathematical models for downstream purification processes.
  • Routinely demonstrate scientific initiative and creativity in research or development activities.
  • Exhibit a strong motivation to implement and advance various innovative technologies in relevant areas across AbbVie.
  • Highly independent and productive in performing laboratory research or method development, requiring only minimal direction from or interaction with supervisor.
  • Formulate conclusions and design follow-on experiments based on multidisciplinary data.
  • A primary author of publications, presentations, regulatory documents and/or primary inventor of patents.
  • Maintain a high level of productivity in the lab and/or pilot plant and cGMP manufacturing facilities.

Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, GxP compliance, and animal care where applicable.No description available


  • Bachelor’s degree or equivalent education and typically 10 years of experience, Master’s degree or equivalent education and typically 8 years of experience, PhD degree or equivalent education and 0-2 years of experience.
  • Education background in chemical engineering, biomedical engineering, biochemistry, biochemical engineering, or biotechnology is preferred.
  • Experience in areas of purification process development is preferred.
  • Demonstrate excellent communication skills and specifically illustrate strong oral and written technical communications.
  • Seamlessly present research outcomes to multifunctional teams
  • Play a strong team player in a cross functional collaborative environment thriving for world class excellence and maintains strong working relationships with internal, global, and external collaborators.
  • Demonstrated problem-solving skills and capability to overcome complex issues.
  • Demonstrated success in coordinating and executing important projects to achieve business goals.
  • Must have a “results-oriented” work ethic and a positive “can-do” attitude with a strong sense of urgency and self-motivated desire to achieve.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

  • This job is eligible to participate in our short-term incentive programs. ​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

  1. Yes, 5% of the Time
$91500 - $173500