Sr. Scientist, Oncology Bioinformatics

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

The Genomic Research Center Oncology Bioinformatics group at AbbVie Bay Area is seeking a highly motivated computational biologist to play an integral role in a multi-disciplinary team focused on developing new therapies and approaches for cancer treatment. AbbVie’s GRC is a center of excellence for bioinformatics, functional genomics, human genetics and pharmacogenomics. The GRC works across all R&D including discovery and clinical development, and multiple areas such as process sciences, global epidemiology, search and evaluation, and corporate strategy.

Based at AbbVie’s brand-new CA headquarters located in South San Francisco, CA, we have an exciting opportunity in the team as the computational oncology lead for AbbVie’s rapidly expanding, enterprise-critical, antibody-drug conjugate (ADC) platform. The candidate will be responsible for interrogating of large-scale data for target, mechanism of action, and biomarker insights; facilitating preclinical experimental design and interpretation, and formulating a data-driven foundation for patient and indication selection strategy of ADC platform in clinic.

We value novel, unique omics data as critical to AbbVie Oncology’s target identification, evaluation, and validation success. Therefore, the successful candidate will drive the ADC cancer data science framework towards AbbVie’s proprietary oncology omics and phenotyping data assets, including patient derived in vivo model, clinical samples, and real-world genomics. The candidate will be a significant contributor to such highly visible effort and interface with cross-functional ADC project teams including AbbVie genomics research community, oncology target discovery, precision medicine, and clinical development.

Key responsibilities include:

·        Lead Oncology Bioinformatics efforts to enable critical data input and impact decision-making of advancing AbbVie’s antibody-drug conjugate platform

·        A key contributor in establishing and executing computational strategy leveraging proprietary multi-modal, pre-clinical and human derived cancer omics data assets for target and biomarker discovery

·        Support and/or expand Companion Diagnostics (CDx) development to enable precision oncology strategy for ADC programs

·        Responsible for formulating scientific questions into coherent analytical efforts, developing rigorous statistical and machine learning methods, and communicating scientific findings to internal and external stakeholders

·        Design novel omics profiling on pre-clinical models and patient tumor samples, and generate insights for ADC target identification and validation through omics-analysis.

·        Contribute to presentations at external scientific conferences, publications in peer-reviewed journals, and regulatory filings

·        Provide expertise and technical consultation for external collaborations / partnerships in academia and industry

Significant Work Activities -Continuous standing for prolonged periods (more than 2 consecutive hours in an 8 hour day)

Basic Qualifications:

·        PhD, or MS in bioinformatics, statistics, mathematics, computer science, computational biology, genomics or a related field with typically 0+ (PhD), 5+ (MS) years of working experience

·        Proficient in at least one general purpose programming/data science languages including but not limited to R, Python, Julia.

·        Experience with common NGS data processing tools, statistical analysis, and machine learning.

·        Understanding of cancer genetics and experience in analyzing multi-modal patient derived tumor genomics data

·        Understanding of cancer biology

·        Project experience in leveraging data science best practice tools: version control, collaborative analysis and documentation

·        Strong communication skills to foster collaboration in cross-functional teams

Preferred:

·        Prior experience with machine-learning based integrative analysis of genomics with proteomics, histomics, or other omics modality

·        Experience with liquid biopsy omics profiling and analysis on cancer patient samples

·        Experience with omics biomarker discovery and validation

·        Familiarity with assay technologies and algorithm principles related epigenetic sequencing (ATAC-seq, methylation, etc.)

·        Understand how to use and leverage containers for deploying standard NGS pipelines (Docker, AWS Container, etc.)

·        Creates a learning environment, open to suggestions and experimentation for improvement.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​
• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs. ​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.