Sr. Scientist II, Cell Biology

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. 

We are currently looking for a highly motivated scientist with a strong knowledge of targeted protein degradation (TPD) and/or the ubiquitin proteasome system (UPS) to join our dynamic cross-functional team. In this role, the selected candidate will have the opportunity to lead a group of biologists in the exploration of the mechanism of action of novel ligase binding ligands. The ideal candidate will have a proven expertise in high throughput assays related to targeted protein degradation. It is essential for the successful candidate to stay up-to-date with relevant internal and external scientific literature and possess the ability to rigorously analyze, document, and report data. Excellent communication skills and proficiency in presenting in front of groups are also required.  Join our team at Abbvie and contribute to ground-breaking research in the field of target protein degradation.

Responsibilities:

• Lead a group of biologists in the development, optimization, and execution of assays to facilitate chemistry efforts in discovering novel ligase binding ligands.
• Conceive and execute independent scientific research to profile the potency, efficacy, and mechanism of action of degraders, including ternary complex formation and ubiquitination, utilizing plate-based biochemical/cellular assays and quantitative western blot.
• Innovate by developing novel cellular & biochemical assays to support structure-activity relationship (SAR) studies for degraders.
• Collaborate with Therapeutic Area and Platform biology leads to drive and contribute to pipeline projects.
• Exhibit a high level of initiative and proficiency in troubleshooting experiments and lead by example in maintaining high standards in data analysis and quality.
• Maintain accurate written records of laboratory procedures and effectively communicate research findings in cross-functional project team meetings and publications.

Qualifications:

• PhD in Molecular Biology, Cell Biology, or a related field in Biological Sciences, with at least 4 years of industry experience.
• Strong project leadership and management skills with a proven track record.
• Experience in small molecule drug discovery.
• Expertise or background in ubiquitin proteasome system biology or targeted protein degradation.
• Demonstrated scientific achievement, including a record of publications and presentations related to targeted protein degradation.
• Proven ability to develop, analyze, and interpret assays to address biological questions.
• Proficient in standard biochemical and/or cellular/molecular techniques such as HiBiT, genome editing, Western Blots, ELISA, and NanoBRET.
• Excellent problem-solving and multi-tasking skills in a fast-paced environment
• Must be a team-player with strong oral and written communication skills.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.