Senior Scientist II or Principal Research Scientist I, DNA-encoded Library

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. 

The DNA-encoded Library (DEL) platform group at AbbVie Headquarters in Lake County, Illinois, is seeking a highly talented and motivated scientist to enhance our DEL Chemistry development platform and DEL data analysis capabilities within our Small Molecule Therapeutics and Platform Technologies organization. The individual will work within our DEL Team and collaborate with cross-functional groups including medicinal chemistry, protein sciences, biophysics, and cheminformatics to drive AbbVie DEL platform developments. The successful candidate should possess strong communication and leadership skills and will be expected to contribute to various drug discovery projects across the therapeutic area portfolio of AbbVie interests.

Key Responsibilities:

• Be accountable for the design, development and validation of DELs synthesis schemes with high structural diversity using robust chemistry.
• Supervise efforts to develop, validate, and implement innovative on-DNA chemistry strategies. Provide technical supervision and expertise in standard and innovative synthetic methods as required.
• Interface with Medicinal Chemistry teams to enhance the DEL library portfolio, hit expansion strategy, and hit confirmation activities.
• Contribute to the development of computational tools and methodologies strengthen our DEL data analysis platform and support hit generation activities across AbbVie therapeutic area portfolio.  
• Contribute to the direction and evolution of AbbVie’s DEL platform strategy.

Qualifications:

• BS, MS or Ph.D. in Computational Chemistry, Medicinal Chemistry, or related discipline with typically 4-6+ (PhD), 10-12+ (MS) or 12-14+ (BS) years of experience.
• In-depth knowledge and experience in all aspects of the DNA-encoded Library platform (i.e., Library design, DEL selections, Next generation Sequencing NGS, data analysis, DEL hit confirmation strategies).
• Experience with modern cheminformatics tools, computational tools, data visualization, and statistical analysis of large data sets is preferred.
• A proven track record of scientific publications in successfully applying DEL technology for hit generation against targets of pharmaceutical relevance.
• Demonstrable effective leadership skills.
• Demonstrated a high level of professionalism in working with internal and external collaborators to achieve specific outcomes.
• Excellent analytical and problem-solving skills as well as strong organizational skills.
• Excellent communication and influencing skills.

Position will be filled at level commensurate with extent of education, experience, and accomplishment. Senior Scientist II or Principal Research Scientist I.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

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AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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