Senior Scientist I, Peptide Purification

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Purpose

We are seeking a highly motivated Peptide Purification Scientist to join our Peptide Synthesis team. The ideal candidate will have hands-on experience in the synthesis, transformation, and purification of peptides. This individual will investigate, identify, develop, and optimize new methods/techniques to generate reliable and reproducible data in a timely manner. The candidate should also be able to demonstrate broad and versatile technical expertise within discipline and be able to collaborate and communicate with other groups across discipline.

Responsibilities:

Laboratory Tasks:

• Perform routine laboratory techniques: pipetting, reagent reconstitution, calculation of concentrations/dilutions, and accurate weighing of raw materials for instrument setup and compound processing.

• Use RP-HPLC/MS for purification, characterization, and analysis of peptides.

• Setup, maintain, and troubleshoot instruments: HPLC, lyophilizers, peptide synthesizers, centrifuges, rotovap, and balances.

• Maintain and optimize peptide purification processes to ensure consistent output, with a strong focus on increasing peptide recovery and overall throughput.

• Follow SOPs for standardized activities; implements data driven improvements/optimization.

• Identify and implement process improvements; conduct optimization experiments when necessary.

• Troubleshoot and correct process or instrument issues.

• Highly autonomous and productive in performing laboratory research or method development, requiring only minimal direction from or interaction with supervisor.

• Complete hazardous waste training (RCRA/DOT) and manage hazardous waste, including bulking and coordination with handlers.

Data Analysis & Technical Writing:

• Maintain accurate lab notebooks and records of all procedures.

• Analyze and interpret LC/MS data to assess peptide/sample quality.

• Adjust analytical methods for QC and peptide content.

• Contribute to development of new data analysis methods.

• Prepare and review technical reports, SOPs, summaries, and quantitative analyses.

•Stay current with scientific literature relevant to peptide purification and processes.
 

Inventory & Training:

• Manage inventory of reagents and consumables; order supplies as needed.

• Train new employees in lab techniques and instrument use.

Compliance:

• Comply with all corporate/divisional policies and procedures.

• Adhere to standards regarding code of conduct, safety, handling of hazardous materials, GxP compliance, and animal care (if applicable).
 

Ideal candidates will demonstrate strong problem-solving skills, meticulous attention to detail, and excellent documentation abilities. Experience with RP-HPLC method development and optimization is a must.

Qualifications

List required and preferred qualifications (up to 10). Include education, skills and experience.

• Bachelor’s Degree or equivalent education and typically, 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary.
• Possess thorough theoretical and practical understanding in peptide purification and HPLC method development; experience in peptide synthesis is highly desirable.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time ofthis posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location,and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of anybonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's soleand absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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