Senior Scientist I

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

The Ophthalmology Discovery group at AbbVie is seeking a Senior Scientist I responsible for developing, characterizing, and analyzing sequencing data from pre-clinical in-vitro models of dry age-related macular degeneration (dAMD). The successful candidate should be able to work independently developing stress based in-vitro models using a variety of RPE cell lines to assess dAMD relevant pathways. S/he should have experience with RNA sequencing and develop a systems biology-based approach to create network analysis. Additionally, s/he will be responsible for data collection along with the interpretation and reporting of results to the ophthalmology group.

This individual is expected to consult and share ideas with other scientists in R&D and to create analysis techniques that can be used across the ophthalmology therapeutic area. S/he may serve as a representative to describe the approach to subgroups within the organization. S/he may also be required to train and supervise junior staff members.

Experience in RNA sequencing, systems biology, and omics analysis is required. Experience culturing ARPE19 and iPSCRPE cells in the context of dAMD is essential. Experience in the pharmaceutical industry is preferred. The successful candidate is expected to collaborate with peers in multidiscipline programs or project teams and to advise and consult with other scientists in R&D.

S/he should be highly motivated, with a record of innovation. Emphasis is on the ability to work independently in the lab and function effectively in a matrixed organizational structure. The candidate should have a track record of cross-functional collaborations along with excellent written and oral communication skills.

Specific Responsibilities:

• Design and conduct in-vitro disease models using a variety of RPE cell lines.
• Characterize, perform RNA sequencing, and analyze data from models using a systems biology approach.
• Provide input to drive decisions around data generated from models.
• Provide subject matter expertise around the systems biology approach.
• Present findings from sequencing data on project teams.
• Advise and consult with other scientists in R&D.
• Active scientific participation and collaboration with colleagues in industry and academia

• Scientist with Ph.D. and 0-2 years of pharmaceutical industry or relevant experience
• In-vitro experience, using lines of RPE cells including iPSC derived lines
• Expertise in generating and analyzing RNA sequencing data from in-vitro models of RPE stress.
  • Experience with pathway and functional enrichment analysis, protein-protein network analysis, graph theory, Partek flow and R, DAVID, Reactome, IPA and GSEA, STRING, iRefWeb, and cytoscape, Python, MATLAB (network, igraph, and bioinformatic toolbox)
• Must be able to multitask effectively and be adaptable and flexible to meet changing priorities.
• Committed to the values of integrity, accountability, transparency, scientific rigor, and drive.
• Effective written and verbal communication skills required.
• Excellent collaboration and team skills are required.
• The successful candidate is required to have the ability to work within a diverse workforce.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

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AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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