Senior Scientist, Biologics Purification and Characterization

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Are you ready to make a difference in the world of biologics drug-discovery?

AbbVie's Biologics Discovery Sciences group is on the hunt for a passionate and skilled Senior Scientist to join our innovative team in North Chicago, IL. If you're a creative problem solver with an eye for detail and a drive to advance biologics purification processes, we want you to be part of our journey.

About the Role:

As a Senior Scientist in our dynamic core team, you will focus on the purification of bispecific candidates, ensuring they exhibit suitable purity and characteristics to support advancement into in vitro studies (i.e. drug-like property assays, binding, cell-based assays, etc) and in vivo studies (i.e. efficacy, non-GLP NHP PK, DRF, etc).  We are looking for an independent, driven scientist to champion chromatography efforts to overcome the challenges associated with purifying bispecific proteins.   Your expertise will drive the design and execution of process development strategies that address production liabilities and ensure future process scalability. You will engage in intensive analytical characterization of molecules (end-products/process-intermediates) and extensive methods development to identify and remove process and product related-impurities. 

Key Responsibilities:

• Purification of bispecific candidates at scales ranging from 1g to 200g.
• Design and execute process development strategies to overcome purification challenges.
• Perform intensive analytical characterization of molecules, end-products, by-products, and  process intermediates.
• Collaborate with cross-functional teams to advance drug discovery projects.
• Document and report data with precision, ensuring rigorous scientific communication.

Qualifications:
Position will be hired based on level of experience – Senior Scientist I or Senior Scientist II

• BS, MS, or Ph.D. in Biochemistry, Biophysics, Biochemical Engineering, or a related field with typically 10-12+ years (BS), 8-10+ years (MS), or 0-4+ years (Ph.D.).
• Expertise in all standard bioprocess steps and preparative chromatography techniques, including software systems (Unicorn, Chromeleon, Empower).
• Expertise in AKTA chromatography systems.
• Understanding of molecular- and post-translational protein attributes and their role in protein function.
• Strong problem-solving and analytical skills to address issues such as solubility and aggregation.
• Excellent communication and presentation skills.
• Experience in instrumentation automation is preferred.
• Lifting, carrying, pushing or pulling weights of more than 20 lbs/9 kgs is required.

Drive innovation. Inspire change. Make a difference.
Embark on a rewarding career with AbbVie and help us transform lives through the power of biologics discovery.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job maybe eligible to participate in our long-term incentive programs​.

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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