Principal Research Scientist II, Ophthalmology

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. 

The Ophthalmology Discovery group at AbbVie is seeking a Principal Scientist II responsible for the design and implementation of pre-clinical in vivo studies to identify, validate, and characterize potential therapeutic targets and assets to support ophthalmic drug discovery and development programs. The successful candidate will lead and contribute to the implementation of strategies for the discovery and validation of targets in ophthalmology. As a member of multidisciplinary teams, the candidate will be responsible for developing and implementing innovative translatable large animal models of retinal and optic nerve diseases with clinically relevant endpoints. S/he will lead a team that generates disease models using surgical, laser, drug, chemical, or genetic techniques and select and optimize appropriate endpoints. Additionally, s/he will be responsible for data collection and analyses, interpretation, and reporting of results of nonclinical in vivo pharmacology studies.
 

This individual is expected to advise and consult with other scientists in R&D as well as outside collaborators and to work with the Eye Care Research leadership team to help set strategy. S/he may serve as a pharmacology representative on nonclinical and translational sub-teams and assignments and will act as a subject matter expert on behalf of AbbVie to external parties, including external collaborations. S/he will also be required to train and supervise junior staff members.

Experience in the fields of ophthalmology or vision research is required. A comprehensive understanding of models of ophthalmic disease, functional vision assessments, and ophthalmic imaging modalities is essential. Prior drug discovery and development is an asset. The successful candidate is expected to collaborate with peers in multidiscipline programs or project teams and to advise and consult with other scientists in R&D as well as outside collaborators.

S/he should be highly motivated, with a record of innovation and scientific leadership. Emphasis is on the ability to demonstrate scientific leadership skills and function effectively in a matrixed organizational structure. The candidate should have a track record of cross-functional collaborations along with excellent written and oral communication skills.

Specific responsibilities:

• Design and conduct in vivo nonclinical pharmacology studies.
• Analyze, interpret, and report in vivo pharmacology datasets.
• Provide input to drive decisions to advance Discovery projects.
• Provide subject matter expertise in animal models of ocular diseases and ocular and visual functions.  
• Represent Research Pharmacology on project teams.
• Advise and consult with other scientists in R&D as well as outside collaborators.
• Manage people, including employee engagement and career development.
• Active scientific participation and collaboration with colleagues in industry and academia

• Vision Scientist with Ph.D. and 8 years of pharmaceutical industry or relevant experience
• Expertise in models of ophthalmic disease, functional vision assessments, and ophthalmic imaging modalities, as well as the application of these techniques to pharmacological studies
  • Experience with a range of ocular imaging modalities, including angiography and autofluorescence, fundus and vitreal photography, ocular coherence tomography (OCT), slit lamp biomicroscopy, gonioscopy, specular microscopy, ultrasonography, and ophthalmoscopy required
  • Knowledge of functional in vivo endpoints including vision psychophysics, ocular electrophysiology (ERG, VEP) required.
• Must be able to multitask effectively and be adaptable and flexible to meet changing priorities.
• Committed to the values of integrity, accountability, transparency, scientific rigor, and drive.
• Effective written and verbal communication skills required.
• Excellent collaboration and team skills are required.
• The successful candidate is required to have the ability to work within a diverse workforce.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

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AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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