2024 Twin Screw Granulation Intern

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Twin Screw Granulation Internship Overview

Envision spending your summer working with energetic colleagues and inspirational leaders, all while gaining world-class experience in one of the most dynamic organizations in the pharmaceutical industry. This is a reality for AbbVie Interns.

AbbVie’s Small Molecule Chemistry, Manufacturing and Controls (CMC) Development team plays a key role in developing novel small molecule chemical entities into robust drug products for clinical studies and commercial launch. Under supervision of experienced research scientists, the intern will support the Small Molecule CMC development team in establishing approaches to assess and model evolution of material properties (e.g. API particle size change) during twin screw granulation for the manufacture of oral dosage forms. In this exciting opportunity, the intern will develop approaches to quantify raw material particle size changes in multi-component granules, conduct granulation studies using twin screw granulator, and build a model(s) that connect material properties to the extent of particle size changes in such processes.

Key responsibilities include:

• Identify key material physical property attributes (such as mechanical properties, morphology, size) for particle breakage.
• Conduct granulation studies and establish process conditions/excipient choice that would reduce/mitigate effects of raw material breakages.
• Develop new approaches to quantify raw material particle size in multi-component granules.
• Develop model to address underlying breakage rate and mechanism in combination of computational Particle Informatics tools.

Minimum Qualifications  

• Currently enrolled in university, pursuing a PhD in Chemical Engineering, Physical Pharmacy, Pharmaceutical Sciences, Materials Science & Engineering, or other related field.
• Must be enrolled in university for at least one semester following the internship.

Preferred Qualifications  

• Expected graduation date between December 2024 – July 2025.
• Fundamental understanding of physicochemical properties as related to formulation design.
• Working knowledge of twin-screw processing and/or breakage processes used in pharmaceutical manufacturing.
• Experience in the development of first-principle or empirical model to relate material properties to process and performance.
• Experience with analytical approaches toward physical property characterization of small-molecule candidates (i.e. particle size, PXRD, microscopy, etc.)
• Self-motivated; ability to execute with limited supervision and direction. Can work independently or part of a team.
• Demonstrate excellent communication skills and specifically illustrate strong oral and written technical communications.

Benefits and Amenities

• Competitive pay.
• Relocation support for eligible students.
• Opportunity to connect with Abbvie leaders and scientists.
• Exposure to state-of-the-art facilities and experts in drug substance and drug product development.

Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.