2024 QTAS In vitro ADME Sciences Transporters in Drug Development Research Intern

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

2024 QTAS In Vitro Intern Overview

Envision spending your summer working with energetic colleagues and inspirational leaders, all while gaining world-class experience in one of the most dynamic organizations in the pharmaceutical industry. This is a reality for AbbVie Interns. 

The QTAS group supports Discovery and Development Projects by generating in vitro ADME data, pharmacokinetics characterization, prediction of human efficacious dose/pk and drug-drug interactions (DDI) and in vitro to in vivo extrapolations for clinical candidates. QTAS works closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings. We are looking for a highly motivated student research intern to participate in our internship program. In this role, the intern will gain hands-on experience in the design and conduct of experimental research projects, data analysis, presentation of key scientific findings as well as experience the rich culture of our organization. The selected candidate will gain insight into research approaches related to early drug disposition estimation and support to first-in-human study design. The internship will focus on in-house validation of uptake transporter assay for screening compounds in Discovery.

Key responsibilities include:

• Mammalian cell culture (primary and recombinant).
• Uptake transporter studies (substrate, inhibition, kinetics).
• Hepatocyte uptake studies.
• LC-MS/MS-analysis.
• Estimating tissue clearance, predicting drug-drug interactions potential.
• PBPK modeling and simulations to predict tissue drug exposure and PK-DDI.

Minimum Qualifications  

• Currently enrolled in university, pursuing a PhD or PharmD in Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field.
• Completed at least 2 years of graduate level studies prior to start of internship.
• Must be enrolled in university for at least one semester following the internship.
• Strong self-motivation, organized, and ability to work with other team members, towards a common goal.
• Excellent oral and written communication skills.

Preferred qualifications  

• Expected graduation date between December 2024 – July 2025.  
• Prior experience with in vitro or in vivo membrane transporter studies (pharmacokinetics/disposition) is a plus.
• Knowledge in ADME/DMPK role in drug development.
• Experience in drug-drug interactions (enzyme/transporters) is a plus.
• Hands-on experience with PBPK modeling (Simcyp/GastroPlus) is a plus.
• Working experience with mammalian cells, enzyme kinetics (non-linear data fitting).
• Data analysis/statistics experience.

Benefits and Amenities

• Competitive pay.
• Relocation support for eligible students.
• Opportunity to connect with AbbVie leaders and scientists.

Equal Employment Opportunity at AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.