In Neuroscience Discovery we are looking for an experienced and curious researcher taking a leading role in developing and running mass spectrometry-based analyses supporting in vitro and in vivo activities enabling the development of future therapies in the field of Alzheimer’s and Parkinson’s disease. The lab-based position is located within the Proteostasis Team and focuses on protein homeostasis, misfolding and degradation in the context of neurodegenerative diseases.
Key responsibilities include:
- You will take a leading role in developing and running mass spectrometry-based analyses supporting in vitro and in vivo activities of Neuroscience Discovery
- As a member of the Proteostasis’ team you will design, execute, and interpret critical (phospho-) proteomic studies for demonstration of Mode-of-Action (MoA), and advancement of pipeline projects through milestones
- You will cross-functionally work together with colleagues from Computational Biology and in vivo Pharmacology, as well as global teams supporting MoA and Proof-of-Principle studies
- You will be jointly responsible for keeping our mass spectrometers and associated HPLCs operating and train less experienced colleagues in using respective instruments. You will act as a back-up for lipidome analyses.
- In the Neuroscience Discovery organization, you will engage yourself in identification & characterization of novel targets for treatment of neurodegenerative diseases, esp. Alzheimer dementia as well as Parkinson’s disease, and follow the technological landscape of mass spectrometry regarding new methods and instrumentation.
- Bachelor’s Degree or equivalent education and typically 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary, ideally in chemistry, biology or pharmacy
- You gained hands-on expertise in operating mass spectrometers for at least 3 years.
- You are highly skilled in operating and daily maintenance of Nano-HPLCs and high-resolution mass spectrometers (ideally Orbitrap instruments)
- You have hands-on experience in designing and executing (phospho-) proteomic studies using cells or tissues. You are trained in DDA and DIA analyses and familiar with relevant software, e.g. MaxQuant or Spectronaut
- You are versed in general cell biology and biochemical methodology
- You are skilled to analyze and present data in broader context and eager to defend data during scientific debate
- Additional analytical/technical experience (e. g. CE-MS, automation) is beneficial
- A solid background in Neuroscience / neurodegenerative diseases is advantageous
- As a highly motivated, self-driven and results-oriented person with excellent communication skills you are driven by innovative ways of thinking to improve processes, methods, systems or services
- As a global acting company, we presume proficient English language skills and willingness to learn German
We offer you:
- A challenging job as a scientist in Neuroscience-Discovery with a strong focus on mass spectrometry-based analyses in vitro and in vivo
- Passionate and highly committed colleagues
- We are happy to accompany your on-boarding process and support you during your first steps in your new role
- We provide our employees with high flexibility to tailor their daily work to their individual needs, including flexible work models, multiple benefits, and comprehensive health and sports programs
- Attractive compensation and company benefits, including our excellent occupational health management system, which is one of the best in Germany as well as a wide range of career paths and opportunities for further development
Job Type: Experienced