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De missie van AbbVie is het ontdekken en leveren van innovatieve geneesmiddelen die vandaag een oplossing bieden voor ernstige gezondheidsproblemen en de medische uitdagingen van morgen aanpakken. We streven ernaar om een grote impact te hebben op het leven van mensen in verschillende belangrijke therapeutische domeinen: immunologie, oncologie, neurowetenschappen, oogzorg, virologie, vrouwengezondheid en gastro-enterologie, naast producten en diensten uit de portefeuille van Allergan Aesthetics. Bezoek www.abbvie.com voor meer informatie over AbbVie. Volg @abbvie op Twitter, Facebook, Instagram, YouTube en LinkedIn.

Senior Scientist I, CMC Purification Development

South San Francisco, Californië Job ID 2208154 Categorie Research and Development Afdeling AbbVie

AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs approximately 30,000 people worldwide and markets medicines in more than 170 countries.

Description:


AbbVie is expanding its oncology hub on the West Coast, with AbbVie Bay Area (ABA) in South San Francisco focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work at ABA. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments.  This position is based at AbbVie in the South San Francisco site. 

Position Description:

We are seeking a senior scientist to join a talented team developing purification/downstream processes for biologics GMP applications. In this position the candidate will perform purification development, scale-up, viral clearance and technology transfer activities in a well-supported and dynamic environment to help advance novel cancer therapies to human clinical studies. 

Responsibilities include:

  • Innovate, develop, optimize, and scale-up purification processes
  • Conceive and evaluate novel advanced separation technologies and techniques
  • Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program
  • Transfer processes to GMP manufacturing for clinical material production
  • Work with contract labs and carry out viral clearance studies
  • Write technical publications, reports, presentations, and regulatory filings including publishing research in peer-reviewed journals and presenting work at scientific conferences
  • Work efficiently, collaboratively, and cross-functionally toward project timelines and goals
  • Participate on cross-functional project teams
  • Mentor, supervise and train junior scientists; may be accountable for the effective performance of the team/individuals

 


  • Doctorate (Ph.D.) degree in chemical engineering, bioengineering, or a related field, with at least 0-3 years of experience
  • Must have expertise in protein purification including chromatography separations and filtration operations
  • Able to independently design, execute, and interpret laboratory experiments to answer scientific questions
  • Must be forward-thinking and be able to lead and contribute to scientific/technical discussions
  • Able to independently learn, understand and execute novel/advanced scientific techniques
  • Has excellent attention to detail and ability to keep detailed written records in lab notebook
  • Able to author publications, technical reports, regulatory documents, and presentations
  • Has strong communication skills including verbal, written, and scientific data presentation
  • Has good understanding of biochemistry and bioprocess engineering concepts
  • Able to work collaboratively within and outside of the group
  • Has proficiency with Microsoft Office software, ability to learn new software applications

Preferred:

  • Has a strong understanding of analytical techniques, such as HPLC and ELISA
  • Has hands on experience with monoclonal antibody or antibody-like molecule purification at GMP, pilot and/or laboratory scale
  • Experience with AKTA chromatographic instruments (such as AKTA Avant, AKTA Purifier, AKTA Pure, AKTA Ready or similar)
  • Demonstrated scientific aptitude through authorship of peer-reviewed publications
  • Has a strong understanding of statistical analysis

Significant Work Activities: N/A
Travel: Yes, 5 % of the Time
Job Type: Experienced
Schedule: Full-time
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