We are currently seeking a motivated research scientist with immunohistochemistry, in situ hybridization, and fluorescent and chromogenic multiplexing experience. The candidate will be part of a multidisciplinary team collaborating closely with scientists in the Immunology Discovery Research group to better understand new target expression and biology for the treatment of autoimmune and chronic inflammatory diseases. The successful candidate will work in an exciting, fast-paced environment providing molecular pathology expertise to advance research in target validation, animal model development, biomarkers, and human disease pathogenesis.
Specific activities will include routine histology (microtomy, including cryotomy of frozen tissues, whole-slide scanning), immunohistochemistry (IHC), in situ hybridization (ISH), fluorescent and chromogenic multiplexing, and microscopy to analyze human and animal tissues, 3D culture, and organoid in vitro systems to better understand new target expression and biology.
Our Immunology Discovery Pathology group based in Worcester, MA is leading the evolution of pathology by combining our foundation of deep understanding of disease with IHC multiplexing, spatial transcriptomics, and in vivo imaging to provide unparalleled impact.
- Develop, optimize, and validate high quality and reproducible immunohistochemistry, in situ hybridization, and multiplexing protocols in a drug development setting
- Operate and utilize automated lab equipment, such as Leica Bond Rx IHC/ISH platform, Akoya Polaris spectral imaging instrument, and whole-slide scanning instruments
- Maintain meticulous records and prioritize effectively to deliver results within established timelines
- Work independently and as part of a team
- Communicate effectively providing verbal and written reports to program teams and collaborative scientists
- BS or equivalent education with typically 5-7+ years of experience or MS or equivalent education with typically 2-5+ years of experience.
- Demonstrated expertise in immunohistochemistry, in situ hybridization, and multiplexing method development, optimization, and validation; experience with fluorescence microscopy is desirable
- Relevant histology experience is required; ASCP/HT (HTL) and/or QIHC certification is preferred but not required.
- Highly developed communication skills and a keen ability to engage internal and external team members in collaborative research are also required
- Proficiency in the use of software tools to support data analysis tasks (e.g., GraphPad Prism, Akoya PhenoChart, Excel)
- Ability to build strong relationships with peers and cross functionally with partners outside of team to enable higher performance
- Keen sense of personal responsibility and integrity and strong commitment to quality
- Learns fast, identifies the essential needs of the team, and can change course quickly when indicated
- Raises the bar and is never satisfied with the status quo
- Creates a learning environment and is open to suggestions for improvement
- Embraces the ideas of others and nurtures innovation
Position will be hired based on level of experience.
Significant Work Activities: N/A
Job Type: Experienced