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AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Scientist I/II, Assay Development

Worcester, Massachusetts Req ID 2210953 Category Research and Development Division AbbVie

Purpose:

  • Generate cell lines and conduct assays for screening candidate antibodies and other recombinant biologics from pipeline projects across different therapeutic areas.
  • Design, execute and optimize functional assays for characterizing antibodies using robotic liquid handlers.

Responsibilities:

  • Develop, characterize, and optimize transient and stable cell lines that are used in luminescence and fluorescence based reporter assays, for screening antibodies and other recombinant biologics.
  • Design, optimize, and execute binding assays (e.g. ELISA, flow cytometry) and functional assays (e.g. luminescent and fluorescent reporter cell assays, adhesion, aggregation, phagocytosis, internalization, live-cell imaging etc) for antibody screening and characterization. 
  • Carry out high-throughput screening (HTS) assays using robotic liquid handlers.
  • Collaborate efficiently across different functional groups to achieve goals within project timelines.
  • Analyze data, prepare reports and technical presentations to communicate progress to project teams.

Qualifications: 

  • BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience.
  • Expertise in transient and stable cell line generation through chemical transfection, electroporation and lentiviral transduction methods is required.
  • Expertise in conducting and optimizing assays for antibody characterization and functional screening using FACS, ELISA, luminescence/fluorescent cell-based assays, and live cell imaging is required.
  • Demonstrate ability to independently design, execute and interpret experiments, and master new experimental techniques
  • Demonstrate strong communication and collaboration skills and ability to multi-task and work within timelines
Significant Work Activities: N/A
Travel: No
Job Type: Experienced
Schedule: Full-time
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