AbbVie has an opening for a Conjugation Chemist in Discovery to conduct pre-clinical research and development in the area of antibody drug conjugates (ADCs).

Key Responsibilities Include:

• Synthesis, purification and characterization of ADCs on mg to gram scale under minimal supervision.
• Optimization and validation of conjugation protocols and formulation buffers.
• Optimization of automated techniques for ADC synthesis and purification.

Basic:

• B.S. degree or M.S. degree with 0+ years experience in Analytical Chemistry, Biochemistry, Chemistry, Biomedical Engineering, or other relevant discipline.
• This position requires an individual who is self-motivated, enthusiastic, detail-oriented, with demonstrated problem solving skills who is able to work in a fast-paced team environment. High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential. The successful candidate will join AbbVie’s global ADC conjugation team.
• Knowledge and experience in laboratory scale protein purification, employing Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), and affinity chromatography.
• Knowledge and experience in protein conjugation or labeling.

Preferred:

• Previous experience in the discovery and development of Antibody-Drug Conjugates, including hands-on experience with the conjugation and purification process.
• Hands on experience in analytical techniques including mass spectrometry, HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF).
• Experience with AKTA purification systems.

Position will be hired based on level of experience