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AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Associate Scientist I/II, Conjugation Chemist

Worcester, Massachusetts Req ID 2207846 Category Research and Development Division AbbVie

AbbVie has an opening for a Conjugation Chemist in Discovery to conduct pre-clinical research and development in the area of antibody drug conjugates (ADCs).

Key Responsibilities Include:

  • Synthesis, purification and characterization of ADCs on mg to gram scale under minimal supervision.
  • Optimization and validation of conjugation protocols and formulation buffers.
  • Optimization of automated techniques for ADC synthesis and purification.


  • B.S. degree or M.S. degree with 0+ years experience in Analytical Chemistry, Biochemistry, Chemistry, Biomedical Engineering, or other relevant discipline.
  • This position requires an individual who is self-motivated, enthusiastic, detail-oriented, with demonstrated problem solving skills who is able to work in a fast-paced team environment. High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential. The successful candidate will join AbbVie’s global ADC conjugation team.
  • Knowledge and experience in laboratory scale protein purification, employing Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), and affinity chromatography.
  • Knowledge and experience in protein conjugation or labeling.


  • Previous experience in the discovery and development of Antibody-Drug Conjugates, including hands-on experience with the conjugation and purification process.
  • Hands on experience in analytical techniques including mass spectrometry, HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF).
  • Experience with AKTA purification systems.

Position will be hired based on level of experience


Significant Work Activities: N/A
Travel: No
Job Type: Recent Graduate
Schedule: Full-time

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