AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.
Senior Scientist I, CMC Purification Development
South San Francisco, CaliforniaReq ID 2212060Category Research and DevelopmentDivision AbbVie
AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs approximately 30,000 people worldwide and markets medicines in more than 170 countries.
AbbVie is expanding its oncology hub on the West Coast, with AbbVie Bay Area (ABA) in South San Francisco focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work at ABA. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie in the South San Francisco site.
We are seeking a senior scientist to join a talented team developing purification/downstream processes for biologics GMP applications. In this position the candidate will perform purification development, scale-up, viral clearance and technology transfer activities in a well-supported and dynamic environment to help advance novel cancer therapies to human clinical studies.
Innovate, develop, optimize, and scale-up purification processes
Conceive and evaluate novel advanced separation technologies and techniques
Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program
Transfer processes to GMP manufacturing for clinical material production
Work with contract labs and carry out viral clearance studies
Write technical publications, reports, presentations, and regulatory filings including publishing research in peer-reviewed journals and presenting work at scientific conferences
Work efficiently, collaboratively, and cross-functionally toward project timelines and goals
Participate on cross-functional project teams
Mentor, supervise and train junior scientists; may be accountable for the effective performance of the team/individuals
Doctorate (Ph.D.) degree in chemical engineering, bioengineering, or a related field, with at least 0-3 years of experience
Must have expertise in protein purification including chromatography separations and filtration operations
Able to independently design, execute, and interpret laboratory experiments to answer scientific questions
Must be forward-thinking and be able to lead and contribute to scientific/technical discussions
Able to independently learn, understand and execute novel/advanced scientific techniques
Has excellent attention to detail and ability to keep detailed written records in lab notebook
Able to author publications, technical reports, regulatory documents, and presentations
Has strong communication skills including verbal, written, and scientific data presentation
Has good understanding of biochemistry and bioprocess engineering concepts
Able to work collaboratively within and outside of the group
Has proficiency with Microsoft Office software, ability to learn new software applications
Has a strong understanding of analytical techniques, such as HPLC and ELISA
Has hands on experience with monoclonal antibody or antibody-like molecule purification at GMP, pilot and/or laboratory scale
Experience with AKTA chromatographic instruments (such as AKTA Avant, AKTA Purifier, AKTA Pure, AKTA Ready or similar)
Demonstrated scientific aptitude through authorship of peer-reviewed publications
Has a strong understanding of statistical analysis