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AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Scientist lI, DMPK- BA

Primary South San Francisco, California Req ID 2300524 Category Research and Development Division AbbVie

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie’s new South San Francisco, CA location.



The DMPK-BA department  in South San Francisco, CA is looking for a Scientist I or Scientist II in the ligand binding assay (LBA) group. 

Key responsibilities

  • Develop and validate biomarker LBA methods to support pre-clinical and clinical studies, with the focus on preanalytical sample processing including whole blood, serum, plasma, or PBMC lysate sample generation, biomarker stability evaluation in the handling and storage conditions of such samples.
  • Characterize home-brew or commercial biomarker analytical methods in a fit-for-purpose manner based on biomarker context of use. Follow and contribute to the generation of test methods, draft assay validation plans and validation reports.
  • Employ experience using and choosing LBA platforms and software for data acquisition, analyses and presentations. Employ experience using automation systems for enhanced efficiency and data quality.
  • Perform manual and/or automated validation experiments and sample testing in compliance with Good Scientific Practices (GSPs) and Good Clinical Practices (GCP) guidelines. Review and perform data quality control to ensure integrity and compliance. Document and archive data to ensure traceability and quality.
  • Use computer skills to compile, analyze assay results, and present at group meetings.
  • Prepare buffers and reagents necessary for conducting assay runs. Conduct performance verifications on ligand binding assay lab instruments such as plate washers and plate readers.

  • B.S. in biology, (bio)chemistry, or microbiology with ≥ 5 years relevant experience, or M.S. in highly related academic equivalence with ≥ 2 years relevant experience required.
  • Experience in developing biomarker and PK assays using LBA platforms such as ELISA, MSD, high sensitivity platforms (e.g., SMCxPro and SIMOA), and ideally multiplex platforms such as Luminex, MSD and Olink. Experience in lab automation is a plus.
  • Experience in handling and processing animal and human blood samples for biomarker and drug level measurement. Experience working under GLP/GCP regulation preferred.
  • Key Leadership Competencies

  • Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance.
  • High energy, a quick learner, and working in a cross-functional matrixed environment with attention to detail is critical.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Open to suggestions and embrace the ideas of others, experimentation for improvement.

Applicable to California Applicants Only 

  • The below range is the range that we in good faith believe is the range of possible compensation for this role at the time of this posting. We may ultimately pay more or less than the posted range and this range is only applicable for jobs to be performed in California. This range may be modified in the future. 

  • The salary range for this role is posted below 

  • This job is eligible to participate in our short-term incentive program 

  • This job is eligible to participate in our long-term incentive programs 

  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. 

  • Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company’s sole discretion, consistent with the law. 

AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.

Significant Work Activities: N/A

Travel: No

Job Type: Experienced

Schedule: Full-time


Minimum Salary $74,500

Maximum Salary $145,500

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  • Research and Development, South San Francisco, California, United StatesRemove

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