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AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Scientist I or II, Molecular Biochemistry

South San Francisco, California Req ID 2211323 Category Research and Development Division AbbVie

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie’s new South San Francisco, CA location.

General Position Summary/Purpose:

The Scientist I or II will be a key member of the “Discovery Oncology Assay Team” responsible for providing strong technical expertise and implementation to support drug discovery with special emphasis on assay development, compound screening and automation. The new hire will be responsible for the development and hands on execution of various biochemical, biophysical, and cellular assays suitable for compound screening in HTS/automation mode to support small-molecule drug discovery projects. While the successful candidate engaged in above routine activities, additional responsibilities include bring in novel assay platforms to support departmental project goals and clearly communicate the scientific rationale, methodology and results in written and oral formats.

 

Key Accountabilities/Core Job Responsibilities:

 

  • Design, develop and execute primary/secondary assays in the compound screening funnels and implement strategies to enhance assay throughputs to support various projects that are key to drug discovery pipelines.
  • Hands on experience and fully familiarity on establishing biochemical, biophysical, and cellular assays in HTS format to determine potency and selectivity of small molecules to understand their SAR and mechanism of action.
  • Undertake routine weekly screening activities for various projects that are in top priority to support company’s drug pipeline and product portfolio.
  • Work with supervisors to improve assay protocols and take the leading role in the development, optimization, and validation of new assays. Utilize technical expertise and available information to troubleshoot and resolve key assay hurdles when encountered.
  • Accurately document, critically analyze/interpret data and communicate the results promptly to project leaders.
  • Actively participate in scientific meetings by presenting and critically evaluating emerging scientific literature to facilitate further progress and success of key project assignments.
  • Perform tasks with diligent attention to detail and high level of accuracy. Prioritize tasks and contribute to a highly motivated and productive research team with a sense of urgency and desire to meet project timelines.

General Position Summary/Purpose:

The Scientist I or II will be a key member of the “Discovery Oncology Assay Team” responsible for providing strong technical expertise and implementation to support drug discovery with special emphasis on assay development, compound screening and automation. The new hire will be responsible for the development and hands on execution of various biochemical, biophysical, and cellular assays suitable for compound screening in HTS/automation mode to support small-molecule drug discovery projects. While the successful candidate engaged in above routine activities, additional responsibilities include bring in novel assay platforms to support departmental project goals and clearly communicate the scientific rationale, methodology and results in written and oral formats.

Key Accountabilities/Core Job Responsibilities:

  • Design, develop and execute primary/secondary assays in the compound screening funnels and implement strategies to enhance assay throughputs to support various projects that are key to drug discovery pipelines.
  • Hands on experience and fully familiarity on establishing biochemical, biophysical, and cellular assays in HTS format to determine potency and selectivity of small molecules to understand their SAR and mechanism of action.
  • Undertake routine weekly screening activities for various projects that are in top priority to support company’s drug pipeline and product portfolio.
  • Work with supervisors to improve assay protocols and take the leading role in the development, optimization, and validation of new assays. Utilize technical expertise and available information to troubleshoot and resolve key assay hurdles when encountered.
  • Accurately document, critically analyze/interpret data and communicate the results promptly to project leaders.
  • Actively participate in scientific meetings by presenting and critically evaluating emerging scientific literature to facilitate further progress and success of key project assignments.
  • Perform tasks with diligent attention to detail and high level of accuracy. Prioritize tasks and contribute to a highly motivated and productive research team with a sense of urgency and desire to meet project timelines.

Qualifications:

  • BS with greater than 3 years or MS with greater than 2 years of relevant laboratory experience either in academic or industrial settings.
  • Familiarity with techniques and instrumentation relevant to automated plate-based assays and the use of multiple techniques to execute the desired assays in an HTS format.
  • Proven track record that demonstrates the ability to design, execute and interpret experiments via publications, external presentations, or patents.
  • Strong interpersonal skills to thrive in a team environment. Effective written and verbal communication skills.

Experience:

  • Extensive experience in developing/validating screening assays using purified proteins and cell-based systems including human whole blood or serum samples configured to identify small-molecule inhibitors or binders
  • Experience in designing and executing biochemical and cellular microplate-based assays to identify and characterize small-molecule modulators using established methods such as including FP, TR-FRET, HTRF, nanoBRET, ELISA, MSD, Lab-Chip MSA, FACS and Luminex etc
  • Experience with lab automation, use of liquid handlers (Echo, Bravo, Beckman i-7, Hamilton Nimbus, Mutidrop Combi etc.) and handling/analysis of large data set coming out of screening assays
  • Good knowledge in cell biology models to elucidate molecular mechanisms of action, support SAR activities, and basic protein chemistry technical skills including protein expression, purification, labelling, and characterization by Protein Simple WES and/or Western Blotting
  • Experience with biophysical methods such as SPR, MST, nanoDSF and BLI is a plus but not required
  • Basic knowledge on biological data analysis tools (GraphPad Prism and Microsoft Office tools) and dealing with lab safety and flexibility in taking additional responsibility is expected
Significant Work Activities: N/A
Travel: No
Job Type: Experienced
Schedule: Full-time
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