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About AbbVie

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Scientist I/II, CMC Cell Culture

South San Francisco, California Req ID 2211248 Category Research and Development Division AbbVie

ABOUT THE COMPANY:

AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company spun off from Abbott Laboratories in 2013. AbbVie’s mission is to develop and deliver new medicines to make a remarkable impact on people’s lives. AbbVie employs approximately 50,000 people worldwide and markets medicines in more than 170 countries.

 

DESCRIPTION:

AbbVie is expanding in the West Coast, with AbbVie Bay Area (ABA) in South San Francisco focused on the discovery and development of novel immune-oncology therapeutics. About 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work at ABA. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments.  This position is based at AbbVie in the South San Francisco site. 

 

POSITION DESCRIPTION:

We are seeking a Scientist I/II to join a talented and collaborative team to develop cell culture processes for pre-clinical and clinical manufacture. In this position, the candidate will perform cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel therapeutics into pre-clinical and clinical studies.  

 

Responsibilities:

 

  • Develop cell culture processes for INDa-enabling toxicology studies and Phase I GMP manufacture
  • Use scientific and engineering principles to scale up cell culture processes from ambr250 and/or 2L benchtop scale up to the 4000L scale
  • Use scientific and engineering principles to scale up primary recovery (harvest) processes
  • Collaborate closely with project leads from the Cell Line Development and Purification Development groups to meet dynamic project timelines
  • Lead the tech transfer of master cell banking, cell culture, and primary recovery processes for Phase I GMP manufacture
  • Author and review technical development reports, GMP campaign summary reports and relevant CMC sections for regulatory submissions
  • Lead and/or support the continuous improvement of business processes in the Cell Culture group
  • Develop innovative technologies and enhance our cell culture process understanding
  • Present and/or publish scientific findings at internal forums, external conferences, and/or peer-reviewed journals

 


Required:

  • Bachelor of Science with at least 6 years of industrial CHO cell culture experience or Master of Science with at least 2 years of industrial CHO cell culture experience
  • Proficient in aseptic technique in a biosafety cabinet
  • Proficient in designing and executing and scaling up cell culture processes in the Ambr® 250 and 2L bioreactors
  • Proficient in designing and scaling up primary harvest processes   
  • Hands on experience with single use bioreactors at the 50L to 500L scale and continuous disk stack centrifugation and depth filtration
  • Able to independently design, execute, and interpret laboratory experiments to answer specific scientific questions
  • Forward-thinking and able to lead and contribute to scientific/technical discussions
  • Have excellent attention to detail and the ability to keep detailed written records in an electronic lab notebook or batch record
  • Have strong verbal communications skills and writing skills to clear articulate messages and scientific data to a variety of technical and non-technical audiences
  • Have a strong working understanding of CHO metabolism, cellular transport, and cell culture and primary recovery scale-up principles
  • Proficient with Microsoft Office software (MS Excel, Word, PowerPoint, Outlook, Teams)

Preferred:

  • Experience with media preparation
  • Experience with transient transfection in CHO/HEK cells
  • Experience with designing and analyzing Design of Experiment experiments
  • Experience with late-stage process characterization and validation
  • Experience with programming, i.e., VBA, Java, Python

**Equal Opportunity Employer Minorities/Women/Veterans/Disabled**

Significant Work Activities: N/A
Travel: No
Job Type: Experienced
Schedule: Full-time
ABBVIE

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