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AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Scientist I/II, CMC Cell Culture

South San Francisco, California Req ID 2211248 Category Research and Development Division AbbVie


AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company spun off from Abbott Laboratories in 2013. AbbVie’s mission is to develop and deliver new medicines to make a remarkable impact on people’s lives. AbbVie employs approximately 50,000 people worldwide and markets medicines in more than 170 countries.



AbbVie is expanding in the West Coast, with AbbVie Bay Area (ABA) in South San Francisco focused on the discovery and development of novel immune-oncology therapeutics. About 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work at ABA. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments.  This position is based at AbbVie in the South San Francisco site. 



We are seeking a Scientist I/II to join a talented and collaborative team to develop cell culture processes for pre-clinical and clinical manufacture. In this position, the candidate will perform cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel therapeutics into pre-clinical and clinical studies.  




  • Develop cell culture processes for INDa-enabling toxicology studies and Phase I GMP manufacture
  • Use scientific and engineering principles to scale up cell culture processes from ambr250 and/or 2L benchtop scale up to the 4000L scale
  • Use scientific and engineering principles to scale up primary recovery (harvest) processes
  • Collaborate closely with project leads from the Cell Line Development and Purification Development groups to meet dynamic project timelines
  • Lead the tech transfer of master cell banking, cell culture, and primary recovery processes for Phase I GMP manufacture
  • Author and review technical development reports, GMP campaign summary reports and relevant CMC sections for regulatory submissions
  • Lead and/or support the continuous improvement of business processes in the Cell Culture group
  • Develop innovative technologies and enhance our cell culture process understanding
  • Present and/or publish scientific findings at internal forums, external conferences, and/or peer-reviewed journals



  • Bachelor of Science with at least 6 years of industrial CHO cell culture experience or Master of Science with at least 2 years of industrial CHO cell culture experience
  • Proficient in aseptic technique in a biosafety cabinet
  • Proficient in designing and executing and scaling up cell culture processes in the Ambr® 250 and 2L bioreactors
  • Proficient in designing and scaling up primary harvest processes   
  • Hands on experience with single use bioreactors at the 50L to 500L scale and continuous disk stack centrifugation and depth filtration
  • Able to independently design, execute, and interpret laboratory experiments to answer specific scientific questions
  • Forward-thinking and able to lead and contribute to scientific/technical discussions
  • Have excellent attention to detail and the ability to keep detailed written records in an electronic lab notebook or batch record
  • Have strong verbal communications skills and writing skills to clear articulate messages and scientific data to a variety of technical and non-technical audiences
  • Have a strong working understanding of CHO metabolism, cellular transport, and cell culture and primary recovery scale-up principles
  • Proficient with Microsoft Office software (MS Excel, Word, PowerPoint, Outlook, Teams)


  • Experience with media preparation
  • Experience with transient transfection in CHO/HEK cells
  • Experience with designing and analyzing Design of Experiment experiments
  • Experience with late-stage process characterization and validation
  • Experience with programming, i.e., VBA, Java, Python

**Equal Opportunity Employer Minorities/Women/Veterans/Disabled**

Significant Work Activities: N/A
Travel: No
Job Type: Experienced
Schedule: Full-time

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