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About AbbVie

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Principal Research Scientist II, Medicinal Chemistry

South San Francisco, California Req ID 2210259 Category Research and Development Division AbbVie

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie’s new South San Francisco, CA location.

Principal Research Scientist II, Medicinal Chemistry

South San Francisco, CA
We have an exciting opportunity for an experienced medicinal chemist to join our Small-Molecule Oncology Discovery Chemistry Department at Abbvie Bay Area(ABA) in South San Francisco, CA. The successful candidate will be working with the project director and line manager, he/she will be responsible for driving medicinal chemistry of assigned projects and ensuring the delivery of high-quality tools, leads and candidate molecules within competitive time frames. The candidate will participate in planning and implementing the short-term strategy and long-term vision of the supported project team.



  • Directly contribute to high quality candidate delivery at the bench level as a synthetic chemist.
  • Familiar with modern drug discovery design and modeling tools, able to anticipate challenges and creatively apply knowledge of the latest concepts and technology platforms to solve problems.
  • Responsible for developing medicinal chemistry strategies and ensuring efficient execution of tactics to meet project goals.
  • Provide scientific oversight and accept accountability of medicinal chemistry activities in assigned projects.
  • Manage a medicinal chemistry team of multiple MS/PhD-level scientists within ongoing hit to tool and lead optimization projects, develop the capabilities of the staff through mentoring and by promoting a culture that embraces open scientific debate and agile, accountable decision-making.
  • Ensure the team maintains the highest laboratory safety standards.
  • Effectively augment SAR by coordinating medicinal and synthetic organic chemistry outsourcing activities and collaborations within assigned projects.
  • Quick learner of project biology, DMPK, safety and toxicological data to enable design and interpretation of project study results.
  • Demonstrate strategic thinking and have excellent communication skills, effectively communicate to internal and external partner pharmacology groups and senior management through oral presentations and written reports.
  • Establish strong, productive relationships with key partners and diverse groups across R&D disciplines through clear, transparent communication of medicinal chemistry strategies and progress.
  • Build a strong network and ensure visibility in the medicinal and synthetic organic chemistry field by participation in scientific meetings and by publishing high quality science.

  • PhD/PostDoc in synthetic organic/medicinal chemistry.
  • 10+ (Ph.D) years medicinal chemistry and drug discovery industrial experience.
  • Deep knowledge of biology, pharmacology, and DMPK principles
  • Experience with all phases of drug discovery from hit identification to delivery of development candidates using state-of-the-art platform technologies.
  • Proven ability to innovate and a track record of significant scientific contributions with publications in peer-reviewed journals and protection of intellectual property through patents.
  • Experience in managing, supervising and leading other professionals effectively.
  • Exceptional communication skills, ability to develop, implement and clearly communicate chemistry/project strategies to team, management and collaborators.
  • Strong interpersonal and influencing skills and comfort working in a rapidly changing environment.
  • Ability and track record to lead the delivery of candidate transitions through LO and clinical candidate selection.
  • Ability to work across disease/therapeutic areas and diverse teams.
  • Proficient in assessing patent landscape and independently driving patent filing to protect project intellectual properties
  • Key Leadership Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

  • Equal Opportunity Employer Minorities/Women/Veterans/Disabled

Significant Work Activities: N/A
Travel: No
Job Type: Experienced
Schedule: Full-time

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