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About AbbVie

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Associate Scientist II, Pharmacology

San Francisco, California Req ID 2210157 Category Research and Development Division AbbVie

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie’s new South San Francisco, CA location.

We are seeking a highly motivated individual to join the In Vivo Pharmacology group. The Associate Scientist II will conduct tumor efficacy and PK/PD studies, develop novel preclinical models and provide pharmacology support to innovative cancer drug development. The position will report to Senior Scientist and work collaboratively in a project team setting with biology, medicinal chemistry and DMPK scientists, providing in vivo proof-of-principle for target discovery and validation, formulating and executing efficient in vivo structure activity relationship strategy and advancing oncology programs to clinical development. 

General Position Summary/Purpose: 
Provide preclinical Pharmacology support to Abbvie drug discovery and development projects in oncology. Implement novel experimental approaches to tumor model development, efficacy/PK/PD/ in vivo mechanism-of-action investigation, target discovery and validation, disease mechanisms, resistance biology, and tumor microenvironment interaction in support of drug discovery and development. Investigate, develop, validate or optimize existing and new methods/models to solve project related scientific problems. Generate efficacy and PD data to support preclinical development of drug candidates and regulatory submissions. Develop productive collaborations and communications with other groups across scientific disciplines.

•    Conduct tumor efficacy, imaging and PD studies to support in vivo POC, SAR and IND submission.
•    Report/present analyses of in vivo studies.
•    Understand and adhere to IACUC protocols regarding animal welfare and handling.
•    Cell culture, sorting and genetic manipulation of cells to support efficacy studies and tumor model development.
•    Conduct ex vivo assays such as FACS, MSD, WES and Luminex to understand MOA of in vivo studies.
•    Improve existing Pharmacology workflows and data visualization tools.
•    Commitment to scientific rigor, high data quality and careful documentation.
•    Self-motivated, possess strong problem solving and organizational skills.
•    Ability to manage multiple responsibilities, adapt to changing priorities and meet deadlines in a fast-paced environment.
•    Excellent written and verbal communication skills.
•    Flexibility and motivation to learn techniques and accomplish goals outside those stated above.

QUALIFICATIONS
•    BS/MS in pharmacology, cancer biology, or related field with 0-2 years of drug development experience in a pharmaceutical or biotech industry setting.
•    A strong background in pharmacology and cancer biology.
•    Proficient hands-on experience with tissue culture, tumor implantation, mouse dosing, bleeding and tissue harvesting.
•    Technical experience in flow cytometry, primary cell culture, tissue processing, as well as other standard molecular and cellular biology assays (MSD, ELISA, Wes, etc.) is preferred
•    Strong teamwork spirit, good listener, eager to learn new skills
•    Must be proactive and able to work effectively on multiple experiments in a fast-paced, dynamic environment.
•    Strong written and verbal communication skills, good record keeping and organization skills, attention to details
•    Demonstrated ability to work independently and collaboratively to execute experiments


 



•    BS/MS in pharmacology, cancer biology, or related field with 0-2 years of drug development experience in a pharmaceutical or biotech industry setting.
•    A strong background in pharmacology and cancer biology.
•    Proficient hands-on experience with tissue culture, tumor implantation, mouse dosing, bleeding and tissue harvesting.
•    Technical experience in flow cytometry, primary cell culture, tissue processing, as well as other standard molecular and cellular biology assays (MSD, ELISA, Wes, etc.) is preferred
•    Strong teamwork spirit, good listener, eager to learn new skills
•    Must be proactive and able to work effectively on multiple experiments in a fast-paced, dynamic environment.
•    Strong written and verbal communication skills, good record keeping and organization skills, attention to details
•    Demonstrated ability to work independently and collaboratively to execute experiments

Significant Work Activities: N/A
Travel: No
Job Type: Experienced
Schedule: Full-time
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