We seek a multidisciplinary scientist to join the Technology and Therapeutic Platforms (TTP) department to perform proof of concept experiments to advance novel therapeutic modalities, methods, and platforms involving the use of molecules to influence immunological responses. The successful candidate will apply his or her skills in cell biology, biochemistry, chemical biology, immunology, cancer biology, and/or analytical techniques to demonstrate new possibilities for targeting disease. This person will leverage these skills as a member of a cross-functional team which support s AbbVie’s drug discovery pipeline while interacting with a broad range of Drug Discovery and Development scientists. This dynamic team is also working and innovating to position AbbVie as a leader in the chemical immunology space.

The successful candidate will provide key contributions to advance therapeutic area programs in Immunology and Oncology, as well as contribute to the discovery of emerging therapeutics.

Responsibilities:

• Execute laboratory experiments to demonstrate experimental proof of concept for novel therapeutic modalities.
• Prepare samples from cells and tissues for multiple downstream analyses such as mass spectrometry, flow cytometry, molecular biology readouts, and biochemical assays (e.g., SDS-PAGE, western blotting, and ELISA).
• Cell culture including passaging, maintenance, and pharmacological treatment.
• Tissue processing for downstream analysis.
• Immunopurification/enrichment of proteins for downstream assays.
• Maintain expertise in laboratory techniques and passionately innovate, optimize, and apply new experimental protocols.
• Effectively interpret and communicate results to colleagues.
• Collaborate across multiple projects.

Qualifications

Job level will be commensurate with experience.

Basic:

• Scientist II - BS with typically 7+ years of experience, or MS with typically 5+ years of experience.
• Senior Scientist I - BS with typically 10+ years of experience, MS with typically 8+years of experience, or PhD and no experience necessary.
• A strong research background in cellular/molecular biology, chemical biology, cancer biology, immunology or related field.
• Proficient with cell culture/sterile techniques.
• Expert at basic biochemical techniques including SDS-PAGE, western blot, ELISA.
• Effective verbal and written communication skills.
• Team player and open to tackling new challenges.
• High attention to detail, creativity in problem-solving, and strong interpersonal skills

Preferred:

• Experience performing cell treatments with small molecules or biologics.
• Experience with cellular assays, co-cultures, and functional assays.
• Experience with tissue processing workflows and/or immunoprecipitation.
• Enrichment of proteins/RNA/DNA from cells and tissues, and downstream sample handling for bio-analytical measurements.
• Experience with advanced biochemical assays.
• Experience with flow cytometry.
• Experience preparing samples for downstream applications such as RNA-seq and/or mass-spectrometry based proteomics.

AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.