Purpose:

The primary functions of this position are conducting laboratory experiments and analysis in support of molecular toxicology studies.

Key responsibilities:

• The candidate must be able to multi-task and collaborate successfully across other groups within R&D to identify optimal screening assays for early detection of toxicity liabilities
• Support Preclinical Safety Toxicologists and Pathologists with key in vitro platforms for investigating molecular mechanisms of toxicity and enabling optimal selection of drug candidates.
• Develop/characterize 2D and 3D in vitro platforms, focused on toxicology.
• Produce/coordinate/present key data related to mechanisms of toxicity using in vitro assays or other methods as needed.
• Analyze and interpret relevant molecular toxicology data in a timely manner and communicate data and interpretation to project stakeholders
• Collaboratively transfer in vitro platforms and methods to/from other key groups within AbbVie as needed.

Can hire at Associate Scientist II or Scientist I level based on experience.

Qualifications:

• BS in cell/molecular biology, Molecular toxicology/Pharmacology, biochemistry, or related field with 3+ years of experience or MS in cell/molecular biology, Molecular toxicology/Pharmacology, biochemistry, or related field.
• Experience in basic cell culture and molecular biology (RNA, DNA, protein) endpoints
• Good analytical skills and knowledge in data analysis, interpretation, report writing, and communication (both written and oral)
• Practical knowledge of in vitro assay development and troubleshooting
• Experience with molecular model characterization and imaging endpoint a plus
• Knowledge of traditional scientific, statistical, and graphing software
• Preference will be given to candidates with experience in one or more of the following areas:  gene expression profiling (e.g., RNA-seq, quantitative PCR), gene silencing (siRNA or shRNA), mitochondrial function assays, and/or complex in vitro models (MPS).