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About Allergan Aesthetics

At Allergan Aesthetics, an AbbVie company, we develop, manufacture, and market a portfolio of leading aesthetics brands and products. Our aesthetics portfolio includes facial injectables, body contouring, plastics, skin care, and more. Our goal is to consistently provide our customers with innovation, education, exceptional service, and a commitment to excellence, all with a personal touch. For more information, visit

Sr Scientist II - Microbial Discovery

Irvine, California Req ID 2211194 Category Research and Development Division Allergan Aesthetics

Allergan Aesthetics, an AbbVie Company, is seeking a highly motivated and accomplished Sr. Scientist II who will contribute to a dynamic and multidisciplinary discovery research program by applying innovative microbiological research to engineer bacterial hosts to produce novel protein therapeutics.

The successful candidate should possess extensive and practical experience in strain engineering of anaerobic bacteria to modify and express complex and high value proteins.  We are seeking strong candidates with in-depth knowledge of genetic engineering of microbial organisms, specifically anaerobic bacteria. Knowledge and hands on experience in synthetic biology techniques is required. The successful candidate will preferably have strong molecular biology skills and practical experience applying various genetic editing tools and techniques. Industrial or academic experience is required.  Experience with target protein isolation and purification is desirable.

The successful candidate will have a strong and established background in molecular biology, microbiology, genetics, biochemistry and genetic engineering of microorganisms.  The candidate will have demonstrated the ability to plan and execute high quality, creative scientific work independently as well as in collaboration with others.  This individual will need to design and execute approaches for genetic, microbial strain engineering and evaluation.  He/she will need to organize, analyze, and interpret results independently, make scientific and strategic recommendations, present findings to management and team meetings, and maintain a productive, collaborative and inclusive laboratory environment consistent with regulatory and company expectations.

Key responsibilities:

  • Establish technologies, plan, design and execute the engineering of anaerobic microbial strains to product desired therapeutic proteins.  Confirm strain sequence, evaluate protein expression and contribute to protein isolation.
  • Data analysis and presentation to multidisciplinary teams.
  • Work with cross-functional team members to accomplish the goals and requirements of the organization, including excellence in execution, and workload prioritization.


  • PhD-level education in Molecular Biology, Microbiology, Microbial Physiology, Synthetic Biology, Biochemical Engineering, Biochemistry or related biological science discipline with 6+ years of experience.
  • MS-level education with a minimum of 10 years experience in either academic or industry labaratory setting.
  • Experience in microbial genome engineering using various techniques.
  • Experience using CRISPR/Cas9 tools, homologous recombination, etc for genetic modification
  • Experience designing and implementing screening or selection strategies to identify or validate new strains
  • Experience and understanding of benchtop fermenters; this includes performing routine fermentation operations relating to fermenter prep: assembly/disassembly, sterilization, in process sampling and media/buffer/reagent prep and able to troubleshoot operational and equipment issues.
  • Experience working in anaerobic (glovebox) chambers
  • Ability to perform aseptic cell propagation and manipulation
  • Proficiency with vector cloning and using molecular biology software
  • Proficient with common molecular biology techniques such as PCR, Gibson assembly and DNA transformation
  • Experience with DNA sequencing
  • Able to organize and manage multiple tasks simultaneously to meet deadlines, and excel in a fast-paced environment
  • Must be able to perform daily functions independently with little to no instructions on routine work, and with general instructions on new assignments.
  • Demonstrated success on working productively both independently and within in a team
  • Highly motivated, hands-on experimentalist who thrives in a collaborative, multidisciplinary environment.
  • Maintain a high level of productivity in the lab.
  • Possess strong interpersonal skills with an ability to demonstrate creative ‘out of the box’ thinking to solve difficult problems and champioun new technologies to achieve project goals.
  • Independently responsible for project science within his/her area of expertise.
  • Meticulous attention to detail and diligence in record keeping.
  • Excellent oral and written communication skills.
  • Computer skills: working knowledge of MS-Office (Excel, Word, PowerPoint) is required. Knowledge of graphing software (e.g., GraphPad prism) and basic understanding of statistical analyses is a plus.
Significant Work Activities: N/A
Travel: No
Job Type: Experienced
Schedule: Full-time

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