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AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Scientist II/Senior Scientist I, Immunology Discovery

Cambridge, Massachusetts Req ID 2203636 Category Research and Development Division AbbVie

Our immunology research group in Transformational and Translational Immunology Discovery (TTID) focuses on identifying new targets for treating autoimmune and chronic inflammatory diseases through screenings and omics analysis of human disease tissue-derived datasets. We are also in charge of the validation of targets using in vitro and in vivo experimental approaches. We are seeking a highly-skilled, motivated, and dedicated individual with Immunology laboratory experience both in vitro as well as in vivo. Candidates with immune tolerance induction working experience in T cells, especially regulatory T cells, are highly desired. This position requires passion, attention to details, hands-on experience, and teamwork.

Key responsibilities:

  • Identification and validation of novel targets for the treatment of inflammatory conditions.
  • Development of strategic plans to guide the selection and prioritization of identified targets.
  • Design, execute and generate proof of concept data supporting target Go/No Go decisions using in vitro and in vivo platforms.
  • Perform in vitro human cell-based functional assays and in vivo assays with animal models.
  • Plan and coordinate experiments with internal and external teams.
  • Analyze and present study data, providing scientific interpretations and recommendations in lab meetings and project team meetings.
  • Maintain accurate and well-organized records and laboratory notebooks.
  • Support development of protocols, generate and present study reports.

Basic:

  • BS, MS or PhD in Immunology/Biological Sciences or a related discipline typically 8+ (BS), 5+ (MS), or 0+ (PhD) years of industry experience, with hands-on experience working in a laboratory.
  • Expertise in the study of inflammatory diseases such IBD, Lupus and/or other Rheumatic disorders.
  • Experience executing in vitro cell biology assays and techniques (Flow cytometry, Immunofluorescence imaging, AlphaLISA, ELISA, endpoint analysis, HTRF).
  • Proficiency in molecular biology skills such as qPCR analysis and Western Blotting analysis.
  • Experience executing in vitro studies with human cells, especially human T cells, is required. Working experience with Treg is a plus.
  • Experience executing rodent models of autoimmune disease is required.
  • Experience with CRISPR, gene-editing technology, is a plus.
  • Experience with screenings, preferably CRISPR screening, is a plus.
  • Experience with target validation assay development is a plus.
  • Excellent communication and organizational skills.
  • A quick learner and be a team player.
Significant Work Activities: Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Travel: No
Job Type: Experienced
Schedule: Full-time
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